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|
eF-site ID
|
3phv-A |
|
PDB Code
|
3phv |
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Chain
|
A |
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click to enlarge
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Title
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X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES |
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Classification
|
HYDROLASE |
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Compound
|
UNLIGANDED HIV-1 PROTEASE |
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Source
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Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) |
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Sequence
|
A: |
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG
RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT
PVNIIGRNLLTQIGCTLNF
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Description
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Functional site
|
|
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1)
|
chain |
A |
| residue |
64 |
| type |
SITE |
| sequence |
I
|
| description |
Cleavage; by viral protease => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
64 |
| type |
MOD_RES |
| sequence |
I
|
| description |
Phosphotyrosine; by host => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
A |
| residue |
22-33 |
| type |
prosite |
| sequence |
ALLDTGADDTVL
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
|
| source |
prosite : PS00141
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