eF-site ID 3phj-AB PDB Code 3phj Chain A, B click to enlarge Title Shikimate 5-Dehydrogenase (aroE) from Helicobacter pylori in complex with 3-Dehydroshikimate Classification OXIDOREDUCTASE Compound Shikimate dehydrogenase Source null (AROE_HELPY) Sequence A:  MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYH PILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIK GIALECGAVNTLVLENDELVGYNTDALGFYLSLKYQNALI LGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCD CFMEPPKSAFDLIINATSELPLNKEVLKGYFKEGKLAYDL AYGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSAS QIPYSKAFEVMRSVF B:  MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYH PILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIK GIALECGAVNTLVLENDELVGYNTDALGFYLSLKYQNALI LGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCD CFMEPPKSAFDLIINATSELPLNKEVLKGYFKEGKLAYDL AYGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSAS QIPYSKAFEVMRSVF Description Functional site 1) chain A residue 16 type sequence S description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 2) chain A residue 18 type sequence S description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 3) chain A residue 63 type sequence N description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 4) chain A residue 69 type sequence K description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 5) chain A residue 90 type sequence N description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 6) chain A residue 105 type sequence D description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 7) chain A residue 210 type sequence Y description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 8) chain A residue 237 type sequence Q description BINDING SITE FOR RESIDUE DHK A 500 source : AC1 9) chain B residue 16 type sequence S description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 10) chain B residue 18 type sequence S description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 11) chain B residue 63 type sequence N description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 12) chain B residue 65 type sequence T description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 13) chain B residue 69 type sequence K description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 14) chain B residue 90 type sequence N description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 15) chain B residue 105 type sequence D description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 16) chain B residue 210 type sequence Y description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 17) chain B residue 237 type sequence Q description BINDING SITE FOR RESIDUE DHK B 500 source : AC2 18) chain A residue 208 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00222 source Swiss-Prot : SWS_FT_FI6 19) chain B residue 208 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_00222 source Swiss-Prot : SWS_FT_FI6 20) chain A residue 210 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI7 21) chain B residue 210 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI7 22) chain A residue 69 type ACT_SITE sequence K description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000305|Ref.2, ECO:0000305|Ref.3 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 69 type ACT_SITE sequence K description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000305|Ref.2, ECO:0000305|Ref.3 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 65 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 237 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 16 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 65 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 237 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 16 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0000269|Ref.4 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 105 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 90 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 105 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI3 33) chain A residue 90 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI3 34) chain B residue 125 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2 source Swiss-Prot : SWS_FT_FI4 35) chain B residue 230 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2 source Swiss-Prot : SWS_FT_FI4 36) chain A residue 125 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2 source Swiss-Prot : SWS_FT_FI4 37) chain A residue 230 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|Ref.2 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 181 type BINDING sequence S description BINDING => ECO:0000269|Ref.2 source Swiss-Prot : SWS_FT_FI5 39) chain B residue 181 type BINDING sequence S description BINDING => ECO:0000269|Ref.2 source Swiss-Prot : SWS_FT_FI5

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