eF-site ID 3pgt-AB PDB Code 3pgt Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF HGSTP1-1[I104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE Classification TRANSFERASE Compound PROTEIN (GLUTATHIONE S-TRANSFERASE) Source (GSTP1_HUMAN) Sequence A:  MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQ EGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLY GKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLL LIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYV NLPINGNGKQ B:  PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQE GSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYG KDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVK ALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLL IHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVN LPINGNGKQ Description Functional site 1) chain B residue 142 type sequence F description BINDING SITE FOR RESIDUE SO4 B 210 source : AC1 2) chain B residue 186 type sequence R description BINDING SITE FOR RESIDUE SO4 B 210 source : AC1 3) chain A residue 51 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 210 source : AC2 4) chain B residue 102 type sequence K description BINDING SITE FOR RESIDUE SO4 A 210 source : AC2 5) chain B residue 46 type sequence S description BINDING SITE FOR RESIDUE SO4 B 211 source : AC3 6) chain B residue 54 type sequence K description BINDING SITE FOR RESIDUE SO4 B 211 source : AC3 7) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE SO4 A 211 source : AC4 8) chain A residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 A 212 source : AC5 9) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 212 source : AC5 10) chain B residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 A 212 source : AC5 11) chain B residue 79 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 212 source : AC5 12) chain A residue 190 type sequence K description BINDING SITE FOR RESIDUE SO4 A 213 source : AC6 13) chain B residue 115 type sequence K description BINDING SITE FOR RESIDUE SO4 B 212 source : AC7 14) chain A residue 8 type sequence F description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 15) chain A residue 10 type sequence V description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 16) chain A residue 13 type sequence R description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 17) chain A residue 38 type sequence W description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 18) chain A residue 44 type sequence K description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 19) chain A residue 51 type sequence Q description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 20) chain A residue 52 type sequence L description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 21) chain A residue 53 type sequence P description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 22) chain A residue 64 type sequence Q description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 23) chain A residue 65 type sequence S description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 24) chain A residue 108 type sequence Y description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 25) chain A residue 205 type sequence G description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 26) chain B residue 98 type sequence D description BINDING SITE FOR RESIDUE GBX A 214 source : AC8 27) chain A residue 22 type sequence A description BINDING SITE FOR RESIDUE MES A 215 source : AC9 28) chain A residue 28 type sequence W description BINDING SITE FOR RESIDUE MES A 215 source : AC9 29) chain A residue 30 type sequence E description BINDING SITE FOR RESIDUE MES A 215 source : AC9 30) chain A residue 197 type sequence E description BINDING SITE FOR RESIDUE MES A 215 source : AC9 31) chain A residue 8 type sequence F description BINDING SITE FOR RESIDUE MES A 216 source : BC1 32) chain A residue 35 type sequence V description BINDING SITE FOR RESIDUE MES A 216 source : BC1 33) chain A residue 38 type sequence W description BINDING SITE FOR RESIDUE MES A 216 source : BC1 34) chain A residue 98 type sequence D description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 35) chain B residue 8 type sequence F description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 36) chain B residue 10 type sequence V description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 37) chain B residue 13 type sequence R description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 38) chain B residue 38 type sequence W description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 39) chain B residue 44 type sequence K description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 40) chain B residue 50 type sequence G description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 41) chain B residue 51 type sequence Q description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 42) chain B residue 52 type sequence L description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 43) chain B residue 53 type sequence P description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 44) chain B residue 64 type sequence Q description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 45) chain B residue 65 type sequence S description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 46) chain B residue 108 type sequence Y description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 47) chain B residue 205 type sequence G description BINDING SITE FOR RESIDUE GBX B 213 source : BC2 48) chain B residue 22 type sequence A description BINDING SITE FOR RESIDUE MES B 214 source : BC3 49) chain B residue 28 type sequence W description BINDING SITE FOR RESIDUE MES B 214 source : BC3 50) chain B residue 30 type sequence E description BINDING SITE FOR RESIDUE MES B 214 source : BC3 51) chain B residue 197 type sequence E description BINDING SITE FOR RESIDUE MES B 214 source : BC3 52) chain B residue 8 type sequence F description BINDING SITE FOR RESIDUE MES B 215 source : BC4 53) chain B residue 38 type sequence W description BINDING SITE FOR RESIDUE MES B 215 source : BC4 54) chain A residue 3 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 198 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 3 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 198 type MOD_RES sequence Y description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954 source Swiss-Prot : SWS_FT_FI2 58) chain A residue 61 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 59) chain B residue 61 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 60) chain A residue 102 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P19157 source Swiss-Prot : SWS_FT_FI4 61) chain A residue 115 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P19157 source Swiss-Prot : SWS_FT_FI4 62) chain B residue 102 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P19157 source Swiss-Prot : SWS_FT_FI4 63) chain B residue 115 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P19157 source Swiss-Prot : SWS_FT_FI4 64) chain A residue 127 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 65) chain B residue 127 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 66) chain A residue 7 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 44 type BINDING sequence K description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 51 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 69) chain B residue 64 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 70) chain A residue 13 type BINDING sequence R description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 71) chain A residue 38 type BINDING sequence W description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 72) chain A residue 44 type BINDING sequence K description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 73) chain A residue 51 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 74) chain A residue 64 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 75) chain B residue 7 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 76) chain B residue 13 type BINDING sequence R description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 77) chain B residue 38 type BINDING sequence W description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1

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