eF-site ID 3pds-A PDB Code 3pds Chain A click to enlarge Title Irreversible Agonist-Beta2 Adrenoceptor Complex Classification Membrane Protein/Hydrolase Compound Fusion protein Beta-2 adrenergic receptor/Lysozyme Source Homo sapiens (Human) (ADRB2_HUMAN) Sequence A:  DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVT NYFITSLACADLVMGLAVVPFGAACILMKMWTFGNFWCEF WTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKN KARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEE TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKR QLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSL NAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGIL RNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLR MLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWD AYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL CL Description Functional site 1) chain A residue 90 type sequence G description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 2) chain A residue 93 type sequence C description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 3) chain A residue 99 type sequence W description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 4) chain A residue 109 type sequence W description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 5) chain A residue 113 type sequence D description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 6) chain A residue 114 type sequence V description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 7) chain A residue 191 type sequence C description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 8) chain A residue 192 type sequence D description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 9) chain A residue 193 type sequence F description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 10) chain A residue 200 type sequence A description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 11) chain A residue 203 type sequence S description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 12) chain A residue 207 type sequence S description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 13) chain A residue 286 type sequence W description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 14) chain A residue 289 type sequence F description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 15) chain A residue 290 type sequence F description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 16) chain A residue 293 type sequence N description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 17) chain A residue 308 type sequence Y description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 18) chain A residue 309 type sequence I description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 19) chain A residue 312 type sequence N description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 20) chain A residue 313 type sequence W description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 21) chain A residue 316 type sequence Y description BINDING SITE FOR RESIDUE ERC A 1201 source : AC1 22) chain A residue 65 type sequence Q description BINDING SITE FOR RESIDUE CLR A 1202 source : AC2 23) chain A residue 70 type sequence Y description BINDING SITE FOR RESIDUE CLR A 1202 source : AC2 24) chain A residue 73 type sequence T description BINDING SITE FOR RESIDUE CLR A 1202 source : AC2 25) chain A residue 77 type sequence C description BINDING SITE FOR RESIDUE CLR A 1202 source : AC2 26) chain A residue 154 type sequence I description BINDING SITE FOR RESIDUE CLR A 1202 source : AC2 27) chain A residue 155 type sequence L description BINDING SITE FOR RESIDUE CLR A 1202 source : AC2 28) chain A residue 158 type sequence W description BINDING SITE FOR RESIDUE CLR A 1202 source : AC2 29) chain A residue 66 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 30) chain A residue 67 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 31) chain A residue 68 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 32) chain A residue 131 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 33) chain A residue 141 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 34) chain A residue 143 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1203 source : AC3 35) chain A residue 264 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1204 source : AC4 36) chain A residue 270 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1204 source : AC4 37) chain A residue 273 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1204 source : AC4 38) chain A residue 328 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1204 source : AC4 39) chain A residue 146 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1205 source : AC5 40) chain A residue 147 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1205 source : AC5 41) chain A residue 1040 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1205 source : AC5 42) chain A residue 1114 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1206 source : AC6 43) chain A residue 1115 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1206 source : AC6 44) chain A residue 1116 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1206 source : AC6 45) chain A residue 1117 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1206 source : AC6 46) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1206 source : AC6 47) chain A residue 1142 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1207 source : AC7 48) chain A residue 1143 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1207 source : AC7 49) chain A residue 1144 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1207 source : AC7 50) chain A residue 1145 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1207 source : AC7 51) chain A residue 1092 type sequence D description BINDING SITE FOR RESIDUE SO4 A 1208 source : AC8 52) chain A residue 1093 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1208 source : AC8 53) chain A residue 1096 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1208 source : AC8 54) chain A residue 1119 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1208 source : AC8 55) chain A residue 1011 type catalytic sequence E description 921 source MCSA : MCSA1 56) chain A residue 1020 type catalytic sequence D description 921 source MCSA : MCSA1 57) chain A residue 1032 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 58) chain A residue 1104 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI3 59) chain A residue 265 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI18 60) chain A residue 341 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:17962520, ECO:0000269|PubMed:18547522, ECO:0000269|PubMed:2540197, ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI19 61) chain A residue 119-135 type prosite sequence ASIETLCVIAVDRYFAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAVDRYFaI source prosite : PS00237 62) chain A residue 1011 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 59-71 type TOPO_DOM sequence AKFERLQTVTNYF description Cytoplasmic source Swiss-Prot : SWS_FT_FI6 64) chain A residue 130-150 type TOPO_DOM sequence DRYFAITSPFKYQSLLTKNKA description Cytoplasmic source Swiss-Prot : SWS_FT_FI6 65) chain A residue 96-106 type TOPO_DOM sequence MKMWTFGNFWC description Extracellular source Swiss-Prot : SWS_FT_FI8 66) chain A residue 175-196 type TOPO_DOM sequence RATHQEAINCYAEETCCDFFTN description Extracellular source Swiss-Prot : SWS_FT_FI8 67) chain A residue 299-305 type TOPO_DOM sequence QDNLIRK description Extracellular source Swiss-Prot : SWS_FT_FI8 68) chain A residue 107-129 type TRANSMEM sequence EFWTSIDVLCVTASIETLCVIAV description Helical; Name=3 source Swiss-Prot : SWS_FT_FI9 69) chain A residue 151-174 type TRANSMEM sequence RVIILMVWIVSGLTSFLPIQMHWY description Helical; Name=4 source Swiss-Prot : SWS_FT_FI10 70) chain A residue 306-329 type TRANSMEM sequence EVYILLNWIGYVNSGFNPLIYCRS description Helical; Name=7 source Swiss-Prot : SWS_FT_FI13 71) chain A residue 113 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI14 72) chain A residue 118 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI14 73) chain A residue 293 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI14 74) chain A residue 312 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI14 75) chain A residue 316 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI14 76) chain A residue 203 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17952055, ECO:0000269|PubMed:17962520, ECO:0007744|PDB:2RH1 source Swiss-Prot : SWS_FT_FI15 77) chain A residue 197-220 type TRANSMEM sequence QAYAIASSIVSFYVPLVIMVFVYS description Helical; Name=5 source Swiss-Prot : SWS_FT_FI11 78) chain A residue 72-95 type TRANSMEM sequence ITSLACADLVMGLAVVPFGAACIL description Helical; Name=2 source Swiss-Prot : SWS_FT_FI7 79) chain A residue 141 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8521811 source Swiss-Prot : SWS_FT_FI16 80) chain A residue 1020 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI2 81) chain A residue 1117 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 82) chain A residue 1132 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI4 83) chain A residue 35-58 type TRANSMEM sequence GMGIVMSLIVLAIVFGNVLVITAI description Helical; Name=1 source Swiss-Prot : SWS_FT_FI5 84) chain A residue 275-298 type TRANSMEM sequence LGIIMGTFTLCWLPFFIVNIVHVI description Helical; Name=6 source Swiss-Prot : SWS_FT_FI12

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