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|
eF-site ID
|
3p5j-ABC |
|
PDB Code
|
3p5j |
|
Chain
|
A, B, C |
|
click to enlarge
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Title
|
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease |
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Classification
|
HYDROLASE/REPLICATION |
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Compound
|
Ribonuclease H2 subunit A |
|
Source
|
null (RNH2C_MOUSE) |
|
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Sequence
|
A: |
NTGRCRLSSPVPAVCLKEPCVLGVDEAGRGPVLGPMVYAI
CYCPLSRLADLEALKVATLTENERERLFAKMEEDGDFVGW
ALDVLSPNLISTSMLGRVKYNLNSLSHDTAAGLIQYALDQ
NVNVTQVFVDTVGMPETYQARLQQHFPGIEVTVKAKADSL
FPVVSAASIFAKVARDKAVKNWQFVENLQDLDSDYGSGYP
NDPKTKAWLRKHVDPVFGFPQFVRFSWSTAQAILEKEAED
VIWEDSPHRYFQERGLEAASSL
|
| B: |
AARQLVFLLPEHLKDASSLLFVKLANPHSGEGATYLIDMC
LQQLFEIKVFKEKHHSWFINQSVQSGGLLHFATPMDPLFL
LLHYLLKAGKPDCTLLLRFPELEKSLRHVTEKYYKYSSEK
TLKWLEKKVNQTVVALKANNVNEDYVRYAHGLISDYIPKE
LSDDLSKFLKL
|
| C: |
IHLRPGSLRGAAPAKLHLLPCDVLVSRPAPVDRFFTPAVR
HDADGLQASFRGRGLRGEEVAVPPGFAGFVMVTRLIGATG
SFSHFTLWGLETVPGPDAKVHRALGWPSLAAAIHAQ
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
258 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
2)
|
chain |
A |
| residue |
35 |
| type |
MOD_RES |
| sequence |
E
|
| description |
N-acetylalanine => ECO:0000250|UniProtKB:Q5TBB1
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
142 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylalanine => ECO:0000250|UniProtKB:Q5TBB1
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|