|
|
eF-site ID
|
3p56-DEF |
|
PDB Code
|
3p56 |
|
Chain
|
D, E, F |
|
click to enlarge
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Title
|
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease |
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Classification
|
HYDROLASE/REPLICATION |
|
Compound
|
Ribonuclease H2 subunit A |
|
Source
|
null (RNH2C_HUMAN) |
|
|
Sequence
|
D: |
NTGRCRLSSPVPAVCRKEPCVLGVAEAGRGPVLGPMVYAI
CYCPLPRLADLEALKVATLLESERERLFAKMEDFVGWALD
VLSPNLISTSMLGRVKYNLNSLSHDTATGLIQYALDQGVN
VTQVFVDTKAAALYPVVSAASICAKVARDQAVKKWQDYGS
GYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKE
AEDVIWEDSSHRYFLERGLESATSL
|
| E: |
GARQHVFLVSEYLKDASGLMFVKLVNPCAIYLFNMCLQQL
FEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHY
LIKADKPNCILLLKLPGLEKLLHHVTKYYKYSKEKTLKWL
EKKVNQTVAALKTNNVNEDYIRYAHGLISDYIPKELSD
|
| F: |
VHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIR
QGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTRFIGATA
NFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQ
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
D |
| residue |
34 |
| type |
MOD_RES |
| sequence |
A
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
D |
| residue |
35 |
| type |
MOD_RES |
| sequence |
E
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
D |
| residue |
141 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
D |
| residue |
216 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
D |
| residue |
257 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|