eF-site ID 3p33-G
PDB Code 3p33
Chain G

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Title Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
Classification HORMONE
Compound Insulin
Source Homo sapiens (Human) (INS_HUMAN)
Sequence G:  GIVEQCCTSICSLYQLENYCN
Description (1)  Insulin A chain, insulin B chain


Functional site

1) chain G
residue 6
type
ligand
sequence C
description BINDING SITE FOR RESIDUE IPH G 400
source : BC3

2) chain G
residue 9
type
ligand
sequence S
description BINDING SITE FOR RESIDUE IPH G 400
source : BC3

3) chain G
residue 10
type
ligand
sequence I
description BINDING SITE FOR RESIDUE IPH G 400
source : BC3

4) chain G
residue 11
type
ligand
sequence C
description BINDING SITE FOR RESIDUE IPH G 400
source : BC3

5) chain G
residue 6-7
type binding
ligand IPH: PHENOL
sequence CC
description PHENOL binding site
source pdb_hetatom : IPH_3p33_G_400

6) chain G
residue 9-11
type binding
ligand IPH: PHENOL
sequence SIC
description PHENOL binding site
source pdb_hetatom : IPH_3p33_G_400

7) chain G
residue 16
type binding
ligand IPH: PHENOL
sequence L
description PHENOL binding site
source pdb_hetatom : IPH_3p33_G_400


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