eF-site ID 3p33-F
PDB Code 3p33
Chain F

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Title Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
Classification HORMONE
Compound Insulin
Source Homo sapiens (Human) (INS_HUMAN)
Sequence F:  FVNQHLCGSHLVEALYLVCGERGFFYTPKT
Description (1)  Insulin A chain, insulin B chain


Functional site

1) chain F
residue 10
type
ligand
sequence H
description BINDING SITE FOR RESIDUE ZN F 31
source : AC5

2) chain F
residue 10
type
ligand
sequence H
description BINDING SITE FOR RESIDUE ZN F 31
source : AC5

3) chain F
residue 10
type
ligand
sequence H
description BINDING SITE FOR RESIDUE ZN F 31
source : AC5

4) chain F
residue 10
type
ligand
sequence H
description BINDING SITE FOR RESIDUE CL F 32
source : AC6

5) chain F
residue 10
type
ligand
sequence H
description BINDING SITE FOR RESIDUE CL F 32
source : AC6

6) chain F
residue 10
type
ligand
sequence H
description BINDING SITE FOR RESIDUE CL F 32
source : AC6

7) chain F
residue 5
type
ligand
sequence H
description BINDING SITE FOR RESIDUE IPH E 300
source : BC2

8) chain F
residue 11
type
ligand
sequence L
description BINDING SITE FOR RESIDUE IPH E 300
source : BC2

9) chain F
residue 7
type binding
ligand IPH: PHENOL
sequence C
description PHENOL binding site
source pdb_hetatom : IPH_3p33_E_300

10) chain F
residue 10-11
type binding
ligand IPH: PHENOL
sequence HL
description PHENOL binding site
source pdb_hetatom : IPH_3p33_E_300

11) chain F
residue 14
type binding
ligand IPH: PHENOL
sequence A
description PHENOL binding site
source pdb_hetatom : IPH_3p33_E_300


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