eF-site ID 3p33-E
PDB Code 3p33
Chain E

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Title Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
Classification HORMONE
Compound Insulin
Source Homo sapiens (Human) (INS_HUMAN)
Sequence E:  GIVEQCCTSICSLYQLENYCN
Description (1)  Insulin A chain, insulin B chain


Functional site

1) chain E
residue 6
type
ligand
sequence C
description BINDING SITE FOR RESIDUE IPH E 300
source : BC2

2) chain E
residue 9
type
ligand
sequence S
description BINDING SITE FOR RESIDUE IPH E 300
source : BC2

3) chain E
residue 10
type
ligand
sequence I
description BINDING SITE FOR RESIDUE IPH E 300
source : BC2

4) chain E
residue 11
type
ligand
sequence C
description BINDING SITE FOR RESIDUE IPH E 300
source : BC2

5) chain E
residue 6-7
type binding
ligand IPH: PHENOL
sequence CC
description PHENOL binding site
source pdb_hetatom : IPH_3p33_E_300

6) chain E
residue 9-11
type binding
ligand IPH: PHENOL
sequence SIC
description PHENOL binding site
source pdb_hetatom : IPH_3p33_E_300

7) chain E
residue 16
type binding
ligand IPH: PHENOL
sequence L
description PHENOL binding site
source pdb_hetatom : IPH_3p33_E_300


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