eF-site ID 3p33-C
PDB Code 3p33
Chain C

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Title Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
Classification HORMONE
Compound Insulin
Source Homo sapiens (Human) (INS_HUMAN)
Sequence C:  GIVEQCCTSICSLYQLENYCN
Description (1)  Insulin A chain, insulin B chain


Functional site

1) chain C
residue 6
type
ligand
sequence C
description BINDING SITE FOR RESIDUE IPH C 200
source : BC1

2) chain C
residue 9
type
ligand
sequence S
description BINDING SITE FOR RESIDUE IPH C 200
source : BC1

3) chain C
residue 11
type
ligand
sequence C
description BINDING SITE FOR RESIDUE IPH C 200
source : BC1

4) chain C
residue 6-7
type binding
ligand IPH: PHENOL
sequence CC
description PHENOL binding site
source pdb_hetatom : IPH_3p33_C_200

5) chain C
residue 9-11
type binding
ligand IPH: PHENOL
sequence SIC
description PHENOL binding site
source pdb_hetatom : IPH_3p33_C_200

6) chain C
residue 16
type binding
ligand IPH: PHENOL
sequence L
description PHENOL binding site
source pdb_hetatom : IPH_3p33_C_200


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