eF-site ID 3p33-ABCDEFGH PDB Code 3p33 Chain A, B, C, D, E, F, G, H click to enlarge Title Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity Classification HORMONE Compound Insulin Source Homo sapiens (Human) (INS_HUMAN) Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCGSHLVEALYLVCGERGFFYTPKT C:  GIVEQCCTSICSLYQLENYCN D:  FVNQHLCGSHLVEALYLVCGERGFFYTPKT E:  GIVEQCCTSICSLYQLENYCN F:  FVNQHLCGSHLVEALYLVCGERGFFYTPKT G:  GIVEQCCTSICSLYQLENYCN H:  FVNQHLCGSHLVEALYLVCGERGFFYTPKT Description Functional site 1) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 2) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 3) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 4) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 32 source : AC2 5) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 32 source : AC2 6) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 32 source : AC2 7) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC3 8) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC3 9) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC3 10) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC4 11) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC4 12) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC4 13) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN F 31 source : AC5 14) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN F 31 source : AC5 15) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN F 31 source : AC5 16) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE CL F 32 source : AC6 17) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE CL F 32 source : AC6 18) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE CL F 32 source : AC6 19) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN H 31 source : AC7 20) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN H 31 source : AC7 21) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN H 31 source : AC7 22) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE CL H 32 source : AC8 23) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE CL H 32 source : AC8 24) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE CL H 32 source : AC8 25) chain A residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH A 100 source : AC9 26) chain A residue 9 type sequence S description BINDING SITE FOR RESIDUE IPH A 100 source : AC9 27) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH A 100 source : AC9 28) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH A 100 source : AC9 29) chain B residue 11 type sequence L description BINDING SITE FOR RESIDUE IPH A 100 source : AC9 30) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH C 200 source : BC1 31) chain C residue 9 type sequence S description BINDING SITE FOR RESIDUE IPH C 200 source : BC1 32) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH C 200 source : BC1 33) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE IPH C 200 source : BC1 34) chain E residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH E 300 source : BC2 35) chain E residue 9 type sequence S description BINDING SITE FOR RESIDUE IPH E 300 source : BC2 36) chain E residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH E 300 source : BC2 37) chain E residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH E 300 source : BC2 38) chain F residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH E 300 source : BC2 39) chain F residue 11 type sequence L description BINDING SITE FOR RESIDUE IPH E 300 source : BC2 40) chain G residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH G 400 source : BC3 41) chain G residue 9 type sequence S description BINDING SITE FOR RESIDUE IPH G 400 source : BC3 42) chain G residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH G 400 source : BC3 43) chain G residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH G 400 source : BC3 44) chain H residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH G 400 source : BC3 45) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE IPH G 400 source : BC3 46) chain H residue 11 type sequence L description BINDING SITE FOR RESIDUE IPH G 400 source : BC3 47) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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