|
|
eF-site ID
|
3p33-A |
|
PDB Code
|
3p33 |
|
Chain
|
A |
|
click to enlarge
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|
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Title
|
Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity |
|
Classification
|
HORMONE |
|
Compound
|
Insulin |
|
Source
|
Homo sapiens (Human) (INS_HUMAN) |
|
|
Sequence
|
A: |
GIVEQCCTSICSLYQLENYCN
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
6 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE IPH A 100
|
| source |
: AC9
|
|
|
2)
|
chain |
A |
| residue |
9 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE IPH A 100
|
| source |
: AC9
|
|
|
3)
|
chain |
A |
| residue |
10 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE IPH A 100
|
| source |
: AC9
|
|
|
4)
|
chain |
A |
| residue |
11 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE IPH A 100
|
| source |
: AC9
|
|
|
5)
|
chain |
A |
| residue |
6-20 |
| type |
prosite |
| sequence |
CCTSICSLYQLENYC
|
| description |
INSULIN Insulin family signature. CCTSiCSlyqLenyC
|
| source |
prosite : PS00262
|
|
|
|