eF-site ID 3p2x-ABCD PDB Code 3p2x Chain A, B, C, D click to enlarge Title Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity Classification HORMONE Compound Insulin Source Homo sapiens (Human) (INS_HUMAN) Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCXSHLVEALYLVCGERGFFYTPKT C:  GIVEQCCTSICSLYQLENYCN D:  FVNQHLCXSHLVEALYLVCGERGFFYTPKT Description Functional site 1) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 2) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 3) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC1 4) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC3 5) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC3 6) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC3 7) chain D residue 6 type sequence L description BINDING SITE FOR RESIDUE CL D 32 source : AC4 8) chain D residue 6 type sequence L description BINDING SITE FOR RESIDUE CL D 32 source : AC4 9) chain D residue 6 type sequence L description BINDING SITE FOR RESIDUE CL D 32 source : AC4 10) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC4 11) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC4 12) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL D 32 source : AC4 13) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH C 100 source : AC5 14) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH C 100 source : AC5 15) chain D residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH C 100 source : AC5 16) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE IPH C 100 source : AC5 17) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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