eF-site ID 3onw-B PDB Code 3onw Chain B click to enlarge Title Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif. Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(i) subunit alpha-1 Source Homo sapiens (Human) (RGS14_HUMAN) Sequence B:  REVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKA VVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLA GAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYLLNDS AAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTF KDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYD LVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKK DLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLN KRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNL Description Functional site 1) chain B residue 41 type sequence A description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 2) chain B residue 43 type sequence E description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 3) chain B residue 44 type sequence S description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 4) chain B residue 45 type sequence G description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 5) chain B residue 46 type sequence K description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 6) chain B residue 47 type sequence S description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 7) chain B residue 48 type sequence T description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 8) chain B residue 150 type sequence D description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 9) chain B residue 151 type sequence S description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 10) chain B residue 176 type sequence R description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 11) chain B residue 178 type sequence R description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 12) chain B residue 269 type sequence N description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 13) chain B residue 270 type sequence K description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 14) chain B residue 272 type sequence D description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 15) chain B residue 273 type sequence L description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 16) chain B residue 325 type sequence C description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 17) chain B residue 326 type sequence A description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 18) chain B residue 327 type sequence T description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 19) chain B residue 154 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 1 source : AC3 20) chain B residue 172 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1 source : AC3 21) chain B residue 176 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1 source : AC3 22) chain B residue 242 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2 source : AC4 23) chain B residue 43 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI1 24) chain B residue 269 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI1 25) chain B residue 175 type BINDING sequence L description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI4 26) chain B residue 326 type BINDING sequence A description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI6 27) chain B residue 204 type MOD_RES sequence Q description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI8 28) chain B residue 47 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 181 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 151 type BINDING sequence S description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI3 31) chain B residue 200 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21115486 source Swiss-Prot : SWS_FT_FI5 32) chain B residue 178 type MOD_RES sequence R description ADP-ribosylarginine; by cholera toxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI7

Display surface Download Links