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eF-site ID
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3okj-Z |
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PDB Code
|
3okj |
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Chain
|
Z |
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click to enlarge
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Title
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Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome component Y7 |
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Source
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ORGANISM_COMMON: yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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Z: |
QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE
PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN
DKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKG
AVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQY
EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD
GLEILIVTKDGVRKEFYELKRD
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Description
|
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Functional site
|
|
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1)
|
chain |
Z |
| residue |
114 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE EP9 Y 300
|
| source |
: AC2
|
|
|
2)
|
chain |
Z |
| residue |
118 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE EP9 Y 300
|
| source |
: AC2
|
|
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