eF-site ID 3okj-Y PDB Code 3okj Chain Y click to enlarge Title Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome component Y7 Source ORGANISM_COMMON: yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence Y:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain Y residue 1 type sequence T description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 2) chain Y residue 21 type sequence T description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 3) chain Y residue 22 type sequence A description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 4) chain Y residue 23 type sequence G description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 5) chain Y residue 27 type sequence A description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 6) chain Y residue 31 type sequence V description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 7) chain Y residue 33 type sequence K description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 8) chain Y residue 47 type sequence G description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 9) chain Y residue 48 type sequence G description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 10) chain Y residue 49 type sequence A description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 11) chain Y residue 53 type sequence Q description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 12) chain Y residue 168 type sequence Y description BINDING SITE FOR RESIDUE EP9 Y 300 source : AC2 13) chain Y residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2

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