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eF-site ID
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3okj-L |
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PDB Code
|
3okj |
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Chain
|
L |
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click to enlarge
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Title
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Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome component Y7 |
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Source
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ORGANISM_COMMON: yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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L: |
QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE
PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN
DKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKG
AVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQY
EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD
GLEILIVTKDGVRKEFYELKRD
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Description
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Functional site
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|
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1)
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chain |
L |
| residue |
114 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE EP9 K 300
|
| source |
: AC1
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2)
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chain |
L |
| residue |
118 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE EP9 K 300
|
| source |
: AC1
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|
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3)
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chain |
L |
| residue |
4-51 |
| type |
prosite |
| sequence |
LGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVM
SANGFAAD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD
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| source |
prosite : PS00854
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