eF-site ID 3okj-K PDB Code 3okj Chain K click to enlarge Title Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome component Y7 Source ORGANISM_COMMON: yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence K:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain K residue 1 type sequence T description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 2) chain K residue 21 type sequence T description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 3) chain K residue 22 type sequence A description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 4) chain K residue 23 type sequence G description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 5) chain K residue 27 type sequence A description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 6) chain K residue 31 type sequence V description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 7) chain K residue 33 type sequence K description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 8) chain K residue 47 type sequence G description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 9) chain K residue 48 type sequence G description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 10) chain K residue 49 type sequence A description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 11) chain K residue 53 type sequence Q description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 12) chain K residue 168 type sequence Y description BINDING SITE FOR RESIDUE EP9 K 300 source : AC1 13) chain K residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 14) chain K residue 4-51 type prosite sequence LAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLG TMAGGAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD source prosite : PS00854

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