|
|
eF-site ID
|
3okj-A |
|
PDB Code
|
3okj |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition |
|
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
|
Compound
|
Proteasome component Y7 |
|
Source
|
ORGANISM_COMMON: yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
|
Sequence
|
A: |
MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKAT
NGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGP
DYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQE
ATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWK
ATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESV
EGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTS
QEINDRLEAL
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
8-30 |
| type |
prosite |
| sequence |
YSFSLTTFSPSGKLGQIDYALTA
|
| description |
PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdralSiFSPdGHifQVEYAleA
|
| source |
prosite : PS00388
|
|
|
|