eF-site ID 3oj4-ABCDEF PDB Code 3oj4 Chain A, B, C, D, E, F click to enlarge Title Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex Classification LIGASE/PROTEIN BINDING Compound Ubiquitin-conjugating enzyme E2 D1 Source Homo sapiens (Human) (TNAP3_HUMAN) Sequence A:  MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGP PDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINS NGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV PDIAQIYKSDKEKYNRHAREWTQKYAM B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR C:  SKCRKAGCVYFGTPENKGFCTLCFIEYRENK D:  MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGP PDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINS NGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV PDIAQIYKSDKEKYNRHAREWTQKYAM E:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR F:  SKCRKAGCVYFGTPENKGFCTLCFIEYRENK Description Functional site 1) chain C residue 607 type sequence C description BINDING SITE FOR RESIDUE ZN C 900 source : AC1 2) chain C residue 612 type sequence C description BINDING SITE FOR RESIDUE ZN C 900 source : AC1 3) chain C residue 624 type sequence C description BINDING SITE FOR RESIDUE ZN C 900 source : AC1 4) chain C residue 627 type sequence C description BINDING SITE FOR RESIDUE ZN C 900 source : AC1 5) chain F residue 607 type sequence C description BINDING SITE FOR RESIDUE ZN F 900 source : AC2 6) chain F residue 612 type sequence C description BINDING SITE FOR RESIDUE ZN F 900 source : AC2 7) chain F residue 624 type sequence C description BINDING SITE FOR RESIDUE ZN F 900 source : AC2 8) chain F residue 627 type sequence C description BINDING SITE FOR RESIDUE ZN F 900 source : AC2 9) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 10) chain E residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 11) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 12) chain E residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 13) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 14) chain E residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 16) chain E residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 17) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 18) chain E residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 19) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 20) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 21) chain E residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 22) chain E residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 23) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 24) chain E residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 25) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 26) chain E residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 27) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9 28) chain E residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9 29) chain A residue 74-89 type prosite sequence YHPNINSNGSICLDIL description UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL source prosite : PS00183 30) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 31) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 32) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 33) chain E residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 34) chain E residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 35) chain F residue 607 type SITE sequence C description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 36) chain F residue 612 type SITE sequence C description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 37) chain F residue 624 type SITE sequence C description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 38) chain F residue 627 type SITE sequence C description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1

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