eF-site ID 3ofs-E PDB Code 3ofs Chain E click to enlarge Title Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography Classification HYDROLASE Compound ADP-ribosyl cyclase 1 Source Homo sapiens (Human) (CD38_HUMAN) Sequence E:  WRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSV WDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLW SRIKDLAHQFTQVQRDMFTLADTLLGYLADDLTWCGEFDT SKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVH VMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHG GREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRP Description Functional site 1) chain E residue 125 type sequence W description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 2) chain E residue 126 type sequence S description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 3) chain E residue 127 type sequence R description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 4) chain E residue 145 type sequence L description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 5) chain E residue 189 type sequence W description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 6) chain E residue 193 type sequence S description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 7) chain E residue 196 type sequence F description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 8) chain E residue 220 type sequence S description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 9) chain E residue 221 type sequence T description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 10) chain E residue 222 type sequence F description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 11) chain E residue 226 type sequence E description BINDING SITE FOR RESIDUE AVU E 301 source : AC5 12) chain E residue 164 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 13) chain E residue 219 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 source Swiss-Prot : SWS_FT_FI4 14) chain E residue 209 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 15) chain E residue 100 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 16) chain E residue 201 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1 17) chain E residue 119 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1

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