eF-site ID 3ofs-D PDB Code 3ofs Chain D click to enlarge Title Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography Classification HYDROLASE Compound ADP-ribosyl cyclase 1 Source Homo sapiens (Human) (CD38_HUMAN) Sequence D:  WRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSV WDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLW SRIKDLAHQFTQVQRDMFTLADTLLGYLADDLTWCGEFDT SKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVH VMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHG GDSRDLCQDPTIKELESIISKRNIQFSCKNIYR Description Functional site 1) chain D residue 125 type sequence W description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 2) chain D residue 126 type sequence S description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 3) chain D residue 127 type sequence R description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 4) chain D residue 129 type sequence K description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 5) chain D residue 145 type sequence L description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 6) chain D residue 155 type sequence D description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 7) chain D residue 189 type sequence W description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 8) chain D residue 193 type sequence S description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 9) chain D residue 220 type sequence S description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 10) chain D residue 221 type sequence T description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 11) chain D residue 222 type sequence F description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 12) chain D residue 226 type sequence E description BINDING SITE FOR RESIDUE AVU D 301 source : AC4 13) chain D residue 164 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 14) chain D residue 219 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 source Swiss-Prot : SWS_FT_FI4 15) chain D residue 100 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 16) chain D residue 209 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 17) chain D residue 119 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1 18) chain D residue 201 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1

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