eF-site ID 3ofs-C PDB Code 3ofs Chain C click to enlarge Title Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography Classification HYDROLASE Compound ADP-ribosyl cyclase 1 Source Homo sapiens (Human) (CD38_HUMAN) Sequence C:  WRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSV WDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLW SRIKDLAHQFTQVQRDMFTLADTLLGYLADDLTWCGEFDT SKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVH VMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHG GREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRP Description Functional site 1) chain C residue 125 type sequence W description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 2) chain C residue 126 type sequence S description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 3) chain C residue 127 type sequence R description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 4) chain C residue 129 type sequence K description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 5) chain C residue 145 type sequence L description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 6) chain C residue 155 type sequence D description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 7) chain C residue 189 type sequence W description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 8) chain C residue 193 type sequence S description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 9) chain C residue 220 type sequence S description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 10) chain C residue 221 type sequence T description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 11) chain C residue 222 type sequence F description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 12) chain C residue 226 type sequence E description BINDING SITE FOR RESIDUE AVU C 301 source : AC3 13) chain C residue 164 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 14) chain C residue 219 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 source Swiss-Prot : SWS_FT_FI4 15) chain C residue 100 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 16) chain C residue 209 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 17) chain C residue 119 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1 18) chain C residue 201 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1

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