eF-site ID 3ofs-B PDB Code 3ofs Chain B click to enlarge Title Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography Classification HYDROLASE Compound ADP-ribosyl cyclase 1 Source Homo sapiens (Human) (CD38_HUMAN) Sequence B:  WRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSV WDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLW SRIKDLAHQFTQVQRDMFTLADTLLGYLADDLTWCGEFDT SKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVH VMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHG EDSRDLCQDPTIKELESIISKRNIQFSCKNIYRP Description Functional site 1) chain B residue 125 type sequence W description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 2) chain B residue 126 type sequence S description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 3) chain B residue 127 type sequence R description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 4) chain B residue 145 type sequence L description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 5) chain B residue 189 type sequence W description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 6) chain B residue 193 type sequence S description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 7) chain B residue 220 type sequence S description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 8) chain B residue 221 type sequence T description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 9) chain B residue 222 type sequence F description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 10) chain B residue 226 type sequence E description BINDING SITE FOR RESIDUE AVU B 301 source : AC2 11) chain B residue 164 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 219 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 source Swiss-Prot : SWS_FT_FI4 13) chain B residue 100 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 209 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 119 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 201 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1

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