eF-site ID 3ofi-B PDB Code 3ofi Chain B click to enlarge Title Crystal structure of human insulin-degrading enzyme in complex with ubiquitin Classification HYDROLASE Compound Insulin-degrading enzyme Source null (UBC_HUMAN) Sequence B:  NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPT TDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYP KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGAL DRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLF QLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELL KFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKN VPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDL QKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGG QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLR AEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILH YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVS KSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKF KLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFK QDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKD SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILL KKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHA MYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR LHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQ LVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQST SENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANG IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAF QKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDN TEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE MNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH Description Functional site 1) chain B residue 108 type sequence H description BINDING SITE FOR RESIDUE ZN B 2012 source : AC3 2) chain B residue 112 type sequence H description BINDING SITE FOR RESIDUE ZN B 2012 source : AC3 3) chain B residue 189 type sequence E description BINDING SITE FOR RESIDUE ZN B 2012 source : AC3 4) chain B residue 205 type sequence E description BINDING SITE FOR RESIDUE DIO B 2013 source : AC4 5) chain B residue 477 type sequence R description BINDING SITE FOR RESIDUE DIO B 2013 source : AC4 6) chain B residue 479 type sequence A description BINDING SITE FOR RESIDUE DIO B 2013 source : AC4 7) chain B residue 800 type sequence Q description BINDING SITE FOR RESIDUE DIO B 2014 source : AC5 8) chain B residue 840 type sequence A description BINDING SITE FOR RESIDUE DIO B 2014 source : AC5 9) chain B residue 841 type sequence N description BINDING SITE FOR RESIDUE DIO B 2014 source : AC5 10) chain B residue 842 type sequence G description BINDING SITE FOR RESIDUE DIO B 2014 source : AC5 11) chain B residue 192 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 12) chain B residue 697 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 13) chain B residue 108 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 14) chain B residue 112 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 15) chain B residue 189 type SITE sequence E description Essential for function source Swiss-Prot : SWS_FT_FI2 16) chain B residue 429 type MOD_RES sequence R description ADP-ribosylglycine => ECO:0000269|PubMed:28525742 source Swiss-Prot : SWS_FT_FI5 17) chain B residue 895 type MOD_RES sequence D description ADP-ribosylglycine => ECO:0000269|PubMed:28525742 source Swiss-Prot : SWS_FT_FI5

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