eF-site ID 3ofi-A PDB Code 3ofi Chain A click to enlarge Title Crystal structure of human insulin-degrading enzyme in complex with ubiquitin Classification HYDROLASE Compound Insulin-degrading enzyme Source null (UBC_HUMAN) Sequence A:  NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPT TDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYP KENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGAL DRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLF QLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELL KFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKN VPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDL QKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGG QKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLR AEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILH YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVS KSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKF KLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFK QDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKD SLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILL KKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHA MYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSR LHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQ LVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQST SENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANG IQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAF QKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDN TEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLARE MNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPH Description Functional site 1) chain A residue 108 type sequence H description BINDING SITE FOR RESIDUE ZN A 2012 source : AC1 2) chain A residue 112 type sequence H description BINDING SITE FOR RESIDUE ZN A 2012 source : AC1 3) chain A residue 189 type sequence E description BINDING SITE FOR RESIDUE ZN A 2012 source : AC1 4) chain A residue 800 type sequence Q description BINDING SITE FOR RESIDUE DIO A 2013 source : AC2 5) chain A residue 840 type sequence A description BINDING SITE FOR RESIDUE DIO A 2013 source : AC2 6) chain A residue 841 type sequence N description BINDING SITE FOR RESIDUE DIO A 2013 source : AC2 7) chain A residue 842 type sequence G description BINDING SITE FOR RESIDUE DIO A 2013 source : AC2 8) chain A residue 913 type sequence S description BINDING SITE FOR RESIDUE DIO A 2013 source : AC2 9) chain A residue 915 type sequence Q description BINDING SITE FOR RESIDUE DIO A 2013 source : AC2 10) chain A residue 189 type SITE sequence E description Essential for function source Swiss-Prot : SWS_FT_FI2

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