eF-site ID 3o3r-B PDB Code 3o3r Chain B click to enlarge Title Crystal Structure of AKR1B14 in complex with NADP Classification OXIDOREDUCTASE Compound Aldo-keto reductase family 1, member B7 Source Rattus norvegicus (Rat) (Q5RJP0_RAT) Sequence B:  TTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYR HFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWS TFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKE FLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSN FNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCH SKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKH KKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQL SEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY Description Functional site 1) chain B residue 19 type sequence G description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 2) chain B residue 20 type sequence T description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 3) chain B residue 21 type sequence W description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 4) chain B residue 22 type sequence K description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 5) chain B residue 44 type sequence D description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 6) chain B residue 49 type sequence Y description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 7) chain B residue 111 type sequence H description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 8) chain B residue 160 type sequence S description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 9) chain B residue 161 type sequence N description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 10) chain B residue 184 type sequence Q description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 11) chain B residue 210 type sequence Y description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 12) chain B residue 211 type sequence S description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 13) chain B residue 212 type sequence P description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 14) chain B residue 213 type sequence L description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 15) chain B residue 214 type sequence G description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 16) chain B residue 215 type sequence S description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 17) chain B residue 216 type sequence P description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 18) chain B residue 217 type sequence D description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 19) chain B residue 246 type sequence A description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 20) chain B residue 261 type sequence I description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 21) chain B residue 262 type sequence P description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 22) chain B residue 263 type sequence K description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 23) chain B residue 264 type sequence S description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 24) chain B residue 265 type sequence V description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 25) chain B residue 266 type sequence T description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 26) chain B residue 269 type sequence H description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 27) chain B residue 272 type sequence E description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 28) chain B residue 273 type sequence N description BINDING SITE FOR RESIDUE NAP B 317 source : AC2 29) chain B residue 78 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 49 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 160 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 184 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 210 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 263 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 273 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 20 type BINDING sequence T description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 44 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2

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