eF-site ID 3o3r-A PDB Code 3o3r Chain A click to enlarge Title Crystal Structure of AKR1B14 in complex with NADP Classification OXIDOREDUCTASE Compound Aldo-keto reductase family 1, member B7 Source Rattus norvegicus (Rat) (Q5RJP0_RAT) Sequence A:  TTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYR HFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWS TFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKE FLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSN FNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCH SKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKH KKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQL SEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY Description Functional site 1) chain A residue 19 type sequence G description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 2) chain A residue 20 type sequence T description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 3) chain A residue 21 type sequence W description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 4) chain A residue 44 type sequence D description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 5) chain A residue 49 type sequence Y description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 6) chain A residue 111 type sequence H description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 7) chain A residue 160 type sequence S description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 8) chain A residue 161 type sequence N description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 9) chain A residue 184 type sequence Q description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 10) chain A residue 210 type sequence Y description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 11) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 12) chain A residue 212 type sequence P description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 13) chain A residue 213 type sequence L description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 14) chain A residue 214 type sequence G description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 15) chain A residue 215 type sequence S description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 16) chain A residue 216 type sequence P description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 17) chain A residue 217 type sequence D description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 18) chain A residue 246 type sequence A description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 19) chain A residue 261 type sequence I description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 20) chain A residue 262 type sequence P description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 21) chain A residue 263 type sequence K description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 22) chain A residue 264 type sequence S description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 23) chain A residue 265 type sequence V description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 24) chain A residue 266 type sequence T description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 25) chain A residue 269 type sequence H description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 26) chain A residue 272 type sequence E description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 27) chain A residue 273 type sequence N description BINDING SITE FOR RESIDUE NAP A 317 source : AC1 28) chain A residue 49 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 160 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 184 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 210 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 263 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 273 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 44 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 20 type BINDING sequence T description BINDING => ECO:0000269|PubMed:21168333 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 78 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 145-162 type prosite sequence MEELVDQGLVKALGVSNF description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdqglVKALGVSNF source prosite : PS00062 38) chain A residue 39-56 type prosite sequence GYRHFDCAYVYQNESEVG description ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHFDCAyvyqnEseVG source prosite : PS00798

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