eF-site ID 3o17-B PDB Code 3o17 Chain B click to enlarge Title Crystal Structure of JNK1-alpha1 isoform Classification TRANSFERASE Compound Mitogen-activated protein kinase 8 Source Homo sapiens (Human) (JIP1_MOUSE) Sequence B:  DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA ILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII GLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK ILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENV DIWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCP AFMKKLQPTVRNYVENRPKYAGYSFEKLFPDVLFPADSEH NKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYD PSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL Description Functional site 1) chain B residue 255 type sequence T description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 2) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 3) chain B residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 4) chain B residue 192 type sequence R description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 5) chain B residue 230 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 6) chain B residue 68 type sequence K description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 7) chain B residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 8) chain B residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 9) chain B residue 150 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 10) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 11) chain B residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 183 type MOD_RES sequence E description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 16) chain B residue 185 type MOD_RES sequence E description Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI5

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