eF-site ID 3o17-ABFG PDB Code 3o17 Chain A, B, F, G click to enlarge Title Crystal Structure of JNK1-alpha1 isoform Classification TRANSFERASE Compound Mitogen-activated protein kinase 8 Source Homo sapiens (Human) (JIP1_MOUSE) Sequence A:  DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA ILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII GLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK ILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENV DIWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCP AFMKKLQPTVRNYVENRPKYAGYSFEKLFPDVLFPADSEH NKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYD PSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL B:  DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA ILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII GLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK ILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENV DIWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCP AFMKKLQPTVRNYVENRPKYAGYSFEKLFPDVLFPADSEH NKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYD PSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL F:  PKRPTTLNLF G:  PKRPTTLNLF Description Functional site 1) chain A residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 2) chain A residue 192 type sequence R description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 3) chain A residue 230 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 4) chain B residue 255 type sequence T description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 5) chain A residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 6) chain A residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 7) chain A residue 150 type sequence R description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 8) chain A residue 255 type sequence T description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 9) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 10) chain B residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 11) chain B residue 192 type sequence R description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 12) chain B residue 230 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 901 source : AC3 13) chain B residue 68 type sequence K description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 14) chain B residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 15) chain B residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 16) chain B residue 150 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 17) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE SO4 B 902 source : AC4 18) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 183 type MOD_RES sequence E description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 23) chain B residue 183 type MOD_RES sequence E description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 185 type MOD_RES sequence E description Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI5 25) chain B residue 185 type MOD_RES sequence E description Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI5 26) chain A residue 147-159 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 27) chain A residue 61-163 type prosite sequence FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEE FQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDC description MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC source prosite : PS01351 28) chain A residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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