eF-site ID 3noa-B PDB Code 3noa Chain B click to enlarge Title Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist Classification TRANSCRIPTION Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQ FRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEII YTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIV TEHVQLLQVIKKTETDMSLHPLLQEIYKDLY Description Functional site 1) chain B residue 255 type sequence L description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 2) chain B residue 280 type sequence R description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 3) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 4) chain B residue 282 type sequence F description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 5) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 6) chain B residue 286 type sequence Q description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 7) chain B residue 289 type sequence S description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 8) chain B residue 323 type sequence H description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 9) chain B residue 327 type sequence Y description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 10) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 11) chain B residue 363 type sequence F description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 12) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 13) chain B residue 367 type sequence K description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 14) chain B residue 449 type sequence H description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 15) chain B residue 453 type sequence L description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 16) chain B residue 469 type sequence L description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 17) chain B residue 473 type sequence Y description BINDING SITE FOR RESIDUE 5BC B 2 source : AC2 18) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 19) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 20) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 21) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 22) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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