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|
eF-site ID
|
3no9-B |
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PDB Code
|
3no9 |
|
Chain
|
B |
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click to enlarge
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Title
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Crystal Structure of apo fumarate hydratase from Mycobacterium tuberculosis |
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Classification
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LYASE |
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Compound
|
Fumarate hydratase class II |
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Source
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Mycobacterium tuberculosis (FUMC_MYCTU) |
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Sequence
|
B: |
ANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLE
RTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIA
DGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTL
HPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLH
DALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQI
EAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVA
VLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVS
LTKIANDIRWMGSGPLTGLAEIQLPDLQPGKVNPVLPEAV
TQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESF
KLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLN
SAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDLSIEDL
DRRLDVLAMAKA
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Description
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Functional site
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|
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1)
|
chain |
B |
| residue |
138 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4ADM, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F91, ECO:0007744|PDB:5F92
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| source |
Swiss-Prot : SWS_FT_FI5
|
|
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2)
|
chain |
B |
| residue |
324 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4ADM, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F91, ECO:0007744|PDB:5F92
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
3)
|
chain |
B |
| residue |
186 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F91, ECO:0007744|PDB:5F92
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
4)
|
chain |
B |
| residue |
187 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305|PubMed:22561013, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4ADM
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
104 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:22561013, ECO:0000269|PubMed:27325754, ECO:0007744|PDB:4ADL, ECO:0007744|PDB:4ADM, ECO:0007744|PDB:4APB, ECO:0007744|PDB:5F92
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
B |
| residue |
128 |
| type |
BINDING |
| sequence |
H
|
| description |
in site B => ECO:0000255|HAMAP-Rule:MF_00743
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
7)
|
chain |
B |
| residue |
331 |
| type |
SITE |
| sequence |
E
|
| description |
Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_00743
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
|