eF-site ID 3nlt-B PDB Code 3nlt Chain B click to enlarge Title Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'S,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}- N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride Classification OXIDOREDUCTASE Compound Nitric oxide synthase, endothelial Source (NOS3_BOVIN) Sequence B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEV ASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFD ARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPG RGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQH GWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEH PTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWY MSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDK AAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKA RGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQP DPW Description Functional site 1) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 2) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 3) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 4) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 5) chain B residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : AC3 6) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC6 7) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC6 8) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 9) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 10) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 11) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 12) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 13) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 14) chain B residue 360 type sequence M description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 15) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 16) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 17) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC7 18) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 600 source : AC8 19) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 600 source : AC8 20) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 600 source : AC8 21) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 600 source : AC8 22) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 23) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 24) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 25) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : AC9 26) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE 3XF B 800 source : BC1 27) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE 3XF B 800 source : BC1 28) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE 3XF B 800 source : BC1 29) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE 3XF B 800 source : BC1 30) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE 3XF B 800 source : BC1 31) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE 3XF B 800 source : BC1 32) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE 3XF B 800 source : BC1 33) chain B residue 83 type sequence Y description BINDING SITE FOR RESIDUE CAD B 950 source : BC2 34) chain B residue 324 type sequence W description BINDING SITE FOR RESIDUE CAD B 950 source : BC2 35) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE CAD B 950 source : BC2 36) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 46) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3

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