eF-site ID 3nl7-AB PDB Code 3nl7 Chain A, B click to enlarge Title Human Hemoglobin A mutant beta H63W carbonmonoxy-form Classification OXYGEN TRANSPORT Compound Hemoglobin subunit alpha Source (HBB_HUMAN) Sequence A:  VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTK TYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR B:  VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQR FFESFGDLSTPDAVMGNPKVKAWGKKVLGAFSDGLAHLDN LKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGK EFTPPVQAAYQKVVAGVANALAHKYH Description Functional site 1) chain A residue 42 type sequence Y description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 2) chain A residue 43 type sequence F description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 3) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 4) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 5) chain A residue 61 type sequence K description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 6) chain A residue 83 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 7) chain A residue 86 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 8) chain A residue 87 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 9) chain A residue 91 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 10) chain A residue 93 type sequence V description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 11) chain A residue 97 type sequence N description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 12) chain A residue 98 type sequence F description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 13) chain A residue 101 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 14) chain A residue 136 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC1 15) chain A residue 29 type sequence L description BINDING SITE FOR RESIDUE CMO A 143 source : AC2 16) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE CMO A 143 source : AC2 17) chain A residue 62 type sequence V description BINDING SITE FOR RESIDUE CMO A 143 source : AC2 18) chain A residue 4 type sequence P description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 19) chain B residue 38 type sequence T description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 20) chain B residue 41 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 21) chain B residue 42 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 22) chain B residue 66 type sequence K description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 23) chain B residue 71 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 24) chain B residue 92 type sequence H description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 25) chain B residue 96 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 26) chain B residue 102 type sequence N description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 27) chain B residue 106 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 28) chain B residue 141 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC3 29) chain B residue 67 type sequence V description BINDING SITE FOR RESIDUE CMO B 148 source : AC4 30) chain B residue 92 type sequence H description BINDING SITE FOR RESIDUE CMO B 148 source : AC4 31) chain B residue 93 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 32) chain A residue 124 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 33) chain A residue 131 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 34) chain A residue 138 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 35) chain B residue 92 type BINDING sequence H description proximal binding residue source Swiss-Prot : SWS_FT_FI3 36) chain A residue 91 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 37) chain A residue 106 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 38) chain A residue 108 type BINDING sequence T description proximal binding residue source Swiss-Prot : SWS_FT_FI3 39) chain A residue 121 type BINDING sequence V description proximal binding residue source Swiss-Prot : SWS_FT_FI3 40) chain A residue 133 type BINDING sequence S description proximal binding residue source Swiss-Prot : SWS_FT_FI3 41) chain A residue 13 type BINDING sequence A description proximal binding residue source Swiss-Prot : SWS_FT_FI3 42) chain A residue 24 type BINDING sequence Y description proximal binding residue source Swiss-Prot : SWS_FT_FI3 43) chain A residue 29 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 44) chain A residue 45 type BINDING sequence H description proximal binding residue source Swiss-Prot : SWS_FT_FI3 45) chain A residue 47 type BINDING sequence D description proximal binding residue source Swiss-Prot : SWS_FT_FI3 46) chain A residue 52 type BINDING sequence S description proximal binding residue source Swiss-Prot : SWS_FT_FI3 47) chain A residue 55 type BINDING sequence V description proximal binding residue source Swiss-Prot : SWS_FT_FI3 48) chain A residue 59 type BINDING sequence G description proximal binding residue source Swiss-Prot : SWS_FT_FI3 49) chain B residue 7 type SITE sequence E description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 50) chain B residue 74 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 51) chain B residue 84 type SITE sequence T description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 52) chain B residue 92 type SITE sequence H description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 53) chain B residue 104 type SITE sequence R description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 54) chain B residue 110 type SITE sequence L description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 55) chain B residue 119 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 56) chain B residue 122 type SITE sequence F description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 57) chain B residue 128 type SITE sequence A description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 58) chain B residue 140 type SITE sequence A description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 59) chain B residue 144 type SITE sequence K description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 60) chain B residue 25 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 61) chain B residue 29 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 62) chain B residue 35 type SITE sequence Y description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 63) chain B residue 37 type SITE sequence W description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 64) chain B residue 45 type SITE sequence F description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 65) chain B residue 52 type SITE sequence D description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 66) chain B residue 56 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 67) chain B residue 71 type SITE sequence F description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 68) chain B residue 9 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 69) chain B residue 44 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 70) chain B residue 144 type MOD_RES sequence K description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI11 71) chain A residue 134 type MOD_RES sequence T description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI11 72) chain A residue 137 type MOD_RES sequence T description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI11 73) chain B residue 1 type CARBOHYD sequence V description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 74) chain A residue 16 type CARBOHYD sequence K description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 75) chain A residue 40 type CARBOHYD sequence K description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 76) chain B residue 8 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 77) chain B residue 17 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 78) chain B residue 66 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 79) chain B residue 120 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 80) chain B residue 144 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI14 81) chain B residue 59 type SITE sequence K description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 82) chain B residue 82 type SITE sequence K description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 83) chain B residue 95 type SITE sequence K description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 84) chain B residue 1 type MOD_RES sequence V description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 85) chain A residue 16 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 86) chain A residue 40 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 87) chain B residue 12 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI8 88) chain B residue 50 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI8 89) chain B residue 87 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI8 90) chain B residue 59 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI9 91) chain B residue 82 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI9 92) chain B residue 1 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 93) chain B residue 2 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 94) chain B residue 82 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 95) chain B residue 143 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 96) chain B residue 63 type BINDING sequence W description distal binding residue source Swiss-Prot : SWS_FT_FI2

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