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eF-site ID
|
3nkm-A |
|
PDB Code
|
3nkm |
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Chain
|
A |
|
click to enlarge
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Title
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Crystal structure of mouse autotaxin |
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Classification
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HYDROLASE |
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Compound
|
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Source
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(ENPP2_MOUSE) |
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Sequence
|
A: |
WTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFD
ELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCC
TNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSV
DGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTF
PNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFN
HRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQ
WLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLRE
IDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTE
FLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIAN
LTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERR
WHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGY
GPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSL
NHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDD
KNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYH
TDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRP
DVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYD
AFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVIS
GPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSC
LDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKW
VEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTY
LHTYE
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Description
|
(1) |
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E.C.3.1.4.39)
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
73-93 |
| type |
prosite |
| sequence |
CRCDNLCKSYSSCCHDFDELC
|
| description |
SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyss.CChDFdelC
|
| source |
prosite : PS00524
|
|
|
2)
|
chain |
A |
| residue |
117-137 |
| type |
prosite |
| sequence |
CHCSEDCLSRGDCCTNYQVVC
|
| description |
SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyss.CChDFdelC
|
| source |
prosite : PS00524
|
|
|
3)
|
chain |
A |
| residue |
852 |
| type |
SITE |
| sequence |
H
|
| description |
Essential for catalytic activity => ECO:0000269|PubMed:19329427
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
4)
|
chain |
A |
| residue |
524 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
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| source |
Swiss-Prot : SWS_FT_FI12
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|
|
5)
|
chain |
A |
| residue |
410 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI12
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|
|
6)
|
chain |
A |
| residue |
243 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000305|PubMed:21240269
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
7)
|
chain |
A |
| residue |
315 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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8)
|
chain |
A |
| residue |
474 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI5
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|
|
9)
|
chain |
A |
| residue |
311 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI5
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|
|
10)
|
chain |
A |
| residue |
358 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH
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| source |
Swiss-Prot : SWS_FT_FI6
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|
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11)
|
chain |
A |
| residue |
743 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
12)
|
chain |
A |
| residue |
745 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI7
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|
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13)
|
chain |
A |
| residue |
739 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
14)
|
chain |
A |
| residue |
741 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
15)
|
chain |
A |
| residue |
747 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5INH, ECO:0007744|PDB:5LIA
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
16)
|
chain |
A |
| residue |
806 |
| type |
CARBOHYD |
| sequence |
D
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
17)
|
chain |
A |
| residue |
53 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5INH
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
18)
|
chain |
A |
| residue |
209 |
| type |
ACT_SITE |
| sequence |
T
|
| description |
Nucleophile => ECO:0000305|PubMed:21240269
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
19)
|
chain |
A |
| residue |
359 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
20)
|
chain |
A |
| residue |
171 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
21)
|
chain |
A |
| residue |
209 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
22)
|
chain |
A |
| residue |
230 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0007744|PDB:3NKR
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
23)
|
chain |
A |
| residue |
306 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0007744|PDB:3NKR
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
24)
|
chain |
A |
| residue |
210 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:21240269, ECO:0007744|PDB:3NKR
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|