eF-site ID 3nka-AB PDB Code 3nka Chain A, B click to enlarge Title Crystal structure of AqpZ H174G,T183F Classification TRANSPORT PROTEIN Compound Aquaporin Z Source (AQPZ_ECOLI) Sequence A:  SHMFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAG VALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPA KEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFAS NGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGATDKFAP AGFAPIAIGLALTLIGLISIPVTNFSVNPARSTAVAIFQG GWALEQLWFFWVVPIVGGIIGGLIYRTLLE B:  SHMFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAG VALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPA KEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFAS NGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGATDKFAP AGFAPIAIGLALTLIGLISIPVTNFSVNPARSTAVAIFQG GWALEQLWFFWVVPIVGGIIGGLIYRTLLEKRD Description Functional site 1) chain A residue 82-102 type TRANSMEM sequence VGYVIAQVVGGIVAAALLYLI description Helical; Name=3 => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 2) chain B residue 82-102 type TRANSMEM sequence VGYVIAQVVGGIVAAALLYLI description Helical; Name=3 => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 3) chain A residue 131-151 type TRANSMEM sequence MLSALVVELVLSAGFLLVIHG description Helical; Name=4 => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 4) chain B residue 131-151 type TRANSMEM sequence MLSALVVELVLSAGFLLVIHG description Helical; Name=4 => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 5) chain A residue 156-176 type TRANSMEM sequence FAPAGFAPIAIGLALTLIGLI description Helical; Name=5 => ECO:0000255 source Swiss-Prot : SWS_FT_FI7 6) chain B residue 156-176 type TRANSMEM sequence FAPAGFAPIAIGLALTLIGLI description Helical; Name=5 => ECO:0000255 source Swiss-Prot : SWS_FT_FI7 7) chain A residue 202-222 type TRANSMEM sequence LEQLWFFWVVPIVGGIIGGLI description Helical; Name=6 => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 8) chain B residue 202-222 type TRANSMEM sequence LEQLWFFWVVPIVGGIIGGLI description Helical; Name=6 => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 9) chain A residue 61-69 type prosite sequence HFNPAVTIG description MIP MIP family signature. HFNPAVTIG source prosite : PS00221 10) chain A residue 128-135 type prosite sequence GYSMLSAL description SPASE_I_1 Signal peptidases I serine active site. GYSMLSAL source prosite : PS00501 11) chain A residue 1-8 type TOPO_DOM sequence MFRKLAAE description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 55-81 type TOPO_DOM sequence GHISGGHFNPAVTIGLWAGGRFPAKEV description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 152-155 type TOPO_DOM sequence ATDK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 1-8 type TOPO_DOM sequence MFRKLAAE description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 55-81 type TOPO_DOM sequence GHISGGHFNPAVTIGLWAGGRFPAKEV description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 152-155 type TOPO_DOM sequence ATDK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 223-231 type TOPO_DOM sequence YRTLLEKRD description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 9-29 type TRANSMEM sequence CFGTFWLVFGGCGSAVLAAGF description Helical; Name=1 => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 9-29 type TRANSMEM sequence CFGTFWLVFGGCGSAVLAAGF description Helical; Name=1 => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 30-33 type TOPO_DOM sequence PELG description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 103-130 type TOPO_DOM sequence ASGKTGFDAAASGFASNGYGEHSPGGYS description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 177-201 type TOPO_DOM sequence SIPVTNFSVNPARSTAVAIFQGGWA description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 30-33 type TOPO_DOM sequence PELG description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 103-130 type TOPO_DOM sequence ASGKTGFDAAASGFASNGYGEHSPGGYS description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 177-201 type TOPO_DOM sequence SIPVTNFSVNPARSTAVAIFQGGWA description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 34-54 type TRANSMEM sequence IGFAGVALAFGLTVLTMAFAV description Helical; Name=2 => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 27) chain B residue 34-54 type TRANSMEM sequence IGFAGVALAFGLTVLTMAFAV description Helical; Name=2 => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 43 type SITE sequence F description Selectivity filter source Swiss-Prot : SWS_FT_FI10 29) chain A residue 174 type SITE sequence G description Selectivity filter source Swiss-Prot : SWS_FT_FI10 30) chain A residue 183 type SITE sequence F description Selectivity filter source Swiss-Prot : SWS_FT_FI10 31) chain A residue 189 type SITE sequence R description Selectivity filter source Swiss-Prot : SWS_FT_FI10 32) chain B residue 43 type SITE sequence F description Selectivity filter source Swiss-Prot : SWS_FT_FI10 33) chain B residue 174 type SITE sequence G description Selectivity filter source Swiss-Prot : SWS_FT_FI10 34) chain B residue 183 type SITE sequence F description Selectivity filter source Swiss-Prot : SWS_FT_FI10 35) chain B residue 189 type SITE sequence R description Selectivity filter source Swiss-Prot : SWS_FT_FI10 36) chain A residue 20 type SITE sequence C description Involved in tetramerization or stability of the tetramer source Swiss-Prot : SWS_FT_FI9 37) chain B residue 20 type SITE sequence C description Involved in tetramerization or stability of the tetramer source Swiss-Prot : SWS_FT_FI9

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