eF-site ID 3ngo-AB PDB Code 3ngo Chain A, B click to enlarge Title Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA Classification HYDROLASE/DNA Compound CCR4-NOT transcription complex subunit 6-like Source Homo sapiens (Human) (3NGO) Sequence A:  LPPRPWITLKERDILPSASFTVMCYNVLCDKYATRQLYGY CPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTL FLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKT EKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVA VVLEVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVS EVKNILEKASIPLVLCADLNSLPDSGVVEYLSNGGVADNH KDFKELYNECLMNFSRITHGFQLKSAYENNLMPYTNYTFD FKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHP HIPSDHFSLLTQLELHP B:  AAAA Description Functional site 1) chain A residue 410 type sequence D description BINDING SITE FOR RESIDUE MG A 556 source : AC1 2) chain A residue 412 type sequence N description BINDING SITE FOR RESIDUE MG A 556 source : AC1 3) chain A residue 488 type sequence I description BINDING SITE FOR RESIDUE MG A 556 source : AC1 4) chain A residue 529 type sequence H description BINDING SITE FOR RESIDUE MG A 556 source : AC1 5) chain B residue 659 type sequence A description BINDING SITE FOR RESIDUE MG A 556 source : AC1 6) chain A residue 240 type sequence E description BINDING SITE FOR RESIDUE MG A 557 source : AC2 7) chain B residue 658 type sequence A description BINDING SITE FOR RESIDUE MG A 557 source : AC2 8) chain B residue 659 type sequence A description BINDING SITE FOR RESIDUE MG A 557 source : AC2 9) chain A residue 410 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGQ source Swiss-Prot : SWS_FT_FI5 10) chain A residue 484 type BINDING sequence F description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI6 11) chain A residue 410 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000305|PubMed:20628353, ECO:0000305|PubMed:27013054 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 240 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 360 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 412 type BINDING sequence N description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 479 type BINDING sequence N description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 276 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGN source Swiss-Prot : SWS_FT_FI3 17) chain A residue 365 type BINDING sequence P description BINDING => ECO:0000269|PubMed:20628353 source Swiss-Prot : SWS_FT_FI4

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