eF-site ID 3ngn-A PDB Code 3ngn Chain A click to enlarge Title Crystal structure of the human CNOT6L nuclease domain in complex with AMP Classification HYDROLASE Compound CCR4-NOT transcription complex subunit 6-like Source Homo sapiens (Human) (CNO6L_HUMAN) Sequence A:  LPPRPWITLKERDSASFTVMCYNVLCDKYATRQLYGYCPS WALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLP ALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKF TLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVL EVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVK NILEKASIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDF KERITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKT HMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQL ELHP Description Functional site 1) chain A residue 240 type sequence E description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 2) chain A residue 360 type sequence H description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 3) chain A residue 363 type sequence W description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 4) chain A residue 365 type sequence P description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 5) chain A residue 371 type sequence K description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 6) chain A residue 410 type sequence D description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 7) chain A residue 412 type sequence N description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 8) chain A residue 479 type sequence N description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 9) chain A residue 484 type sequence F description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 10) chain A residue 529 type sequence H description BINDING SITE FOR RESIDUE AMP A 556 source : AC1 11) chain A residue 174 type sequence W description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 12) chain A residue 188 type sequence S description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 13) chain A residue 190 type sequence T description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 14) chain A residue 271 type sequence I description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 15) chain A residue 272 type sequence M description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 16) chain A residue 273 type sequence S description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 17) chain A residue 276 type sequence E description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 18) chain A residue 535 type sequence Q description BINDING SITE FOR RESIDUE AMP A 557 source : AC2 19) chain A residue 240 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 360 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 412 type BINDING sequence N description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 479 type BINDING sequence N description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 276 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGN source Swiss-Prot : SWS_FT_FI3 24) chain A residue 410 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000305|PubMed:20628353, ECO:0000305|PubMed:27013054 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 365 type BINDING sequence P description BINDING => ECO:0000269|PubMed:20628353 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 410 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGQ source Swiss-Prot : SWS_FT_FI5 27) chain A residue 484 type BINDING sequence F description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:5DV2 source Swiss-Prot : SWS_FT_FI6

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