|
|
eF-site ID
|
3n4i-AB |
|
PDB Code
|
3n4i |
|
Chain
|
A, B |
|
click to enlarge
|
|
|
Title
|
Crystal structure of the SHV-1 D104E beta-lactamase/beta-lactamase inhibitor protein (BLIP) complex |
|
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
|
Compound
|
Beta-lactamase SHV-1 |
|
Source
|
Klebsiella pneumoniae (BLIP_STRCL) |
|
|
Sequence
|
A: |
SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADER
FPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVEY
SPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGP
AGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPAS
MAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVL
PAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRD
TPASMAERNQQIAGIGAALIEHWQR
|
| B: |
AGVMTGAKFTQIQFGMTRQQVLDIAGAENCETGGSFGDSI
HCRGHAAGDYYAYATFGFTSAAADAKVDSKSQEKLLAPSA
PTLTLAKFNQVTVGMTRAQVLATVGQGSCTTWSEYYPAYP
STAGVTLSLSCFDVDGYSSTGFYRGSAHLWFTDGVLQGKR
QWDLV
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
66-81 |
| type |
prosite |
| sequence |
FPMMSTFKVVLCGAVL
|
| description |
BETA_LACTAMASE_A Beta-lactamase class-A active site. FpMMSTfKvvlCGAVL
|
| source |
prosite : PS00146
|
|
|
2)
|
chain |
A |
| residue |
70 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Acyl-ester intermediate
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
168 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
234 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|