eF-site ID 3n0b-ABCD PDB Code 3n0b Chain A, B, C, D click to enlarge Title TM0449 mutant crystals grown in loops/micromounts Classification TRANSFERASE Compound Thymidylate synthase thyX Source Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) (THYX_THEMA) Sequence A:  HMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEE RDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRH RIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVT EKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRAF ATVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCP WTFEAFLKYAYKGDIL B:  MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEER DRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHR IASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTE KISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRAFA TVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPW TFEAFLKYAYKGDILKEVQV C:  MKIDILDKGFVELVDVMGNDLSAVRAARVSFDDEERDRHL IEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASY NELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISE IVDKAYRTYLELIESGVPREVARIVLPLNLYTRAFATVNA RSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEA FLKYAYKGDILKEVQV D:  MKIDILDKGFVELVDVMGNDLSAVRAARVSFDEERDRHLI EYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYN ELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEI VDKAYRTYLELIESGVPREVARIVLPLNLYTRAFATVNAR SLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAF LKYAYKGDIL Description Functional site 1) chain A residue 85 type sequence N description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 2) chain A residue 86 type sequence E description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 3) chain A residue 88 type sequence S description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 4) chain A residue 91 type sequence Y description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 5) chain B residue 30 type sequence S description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 6) chain B residue 55 type sequence T description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 7) chain B residue 58 type sequence E description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 8) chain B residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 9) chain B residue 163 type sequence N description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 10) chain B residue 165 type sequence R description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 11) chain D residue 78 type sequence R description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 12) chain D residue 79 type sequence H description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 13) chain D residue 80 type sequence R description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 14) chain D residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 15) chain D residue 169 type sequence N description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 16) chain D residue 173 type sequence L description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 17) chain D residue 174 type sequence R description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 18) chain D residue 178 type sequence H description BINDING SITE FOR RESIDUE FAD D 300 source : AC1 19) chain A residue 86 type sequence E description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 20) chain A residue 87 type sequence L description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 21) chain A residue 88 type sequence S description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 22) chain A residue 89 type sequence G description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 23) chain A residue 90 type sequence R description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 24) chain A residue 147 type sequence R description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 25) chain D residue 75 type sequence Q description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 26) chain D residue 78 type sequence R description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 27) chain D residue 174 type sequence R description BINDING SITE FOR RESIDUE UMP A 303 source : AC2 28) chain A residue 30 type sequence S description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 29) chain A residue 55 type sequence T description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 30) chain A residue 58 type sequence E description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 31) chain A residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 32) chain A residue 163 type sequence N description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 33) chain A residue 165 type sequence R description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 34) chain B residue 85 type sequence N description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 35) chain B residue 86 type sequence E description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 36) chain B residue 88 type sequence S description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 37) chain B residue 91 type sequence Y description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 38) chain C residue 78 type sequence R description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 39) chain C residue 79 type sequence H description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 40) chain C residue 80 type sequence R description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 41) chain C residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 42) chain C residue 169 type sequence N description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 43) chain C residue 173 type sequence L description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 44) chain C residue 174 type sequence R description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 45) chain C residue 178 type sequence H description BINDING SITE FOR RESIDUE FAD C 305 source : AC3 46) chain B residue 86 type sequence E description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 47) chain B residue 87 type sequence L description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 48) chain B residue 88 type sequence S description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 49) chain B residue 89 type sequence G description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 50) chain B residue 90 type sequence R description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 51) chain B residue 147 type sequence R description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 52) chain C residue 74 type sequence R description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 53) chain C residue 75 type sequence Q description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 54) chain C residue 78 type sequence R description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 55) chain C residue 174 type sequence R description BINDING SITE FOR RESIDUE UMP B 308 source : AC4 56) chain B residue 78 type sequence R description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 57) chain B residue 79 type sequence H description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 58) chain B residue 80 type sequence R description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 59) chain B residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 60) chain B residue 169 type sequence N description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 61) chain B residue 173 type sequence L description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 62) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 63) chain C residue 85 type sequence N description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 64) chain C residue 86 type sequence E description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 65) chain C residue 88 type sequence S description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 66) chain D residue 55 type sequence T description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 67) chain D residue 58 type sequence E description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 68) chain D residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 69) chain D residue 163 type sequence N description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 70) chain D residue 165 type sequence R description BINDING SITE FOR RESIDUE FAD B 310 source : AC5 71) chain B residue 75 type sequence Q description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 72) chain B residue 78 type sequence R description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 73) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 74) chain C residue 77 type sequence F description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 75) chain C residue 86 type sequence E description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 76) chain C residue 87 type sequence L description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 77) chain C residue 88 type sequence S description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 78) chain C residue 89 type sequence G description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 79) chain C residue 90 type sequence R description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 80) chain C residue 147 type sequence R description BINDING SITE FOR RESIDUE UMP C 313 source : AC6 81) chain A residue 78 type sequence R description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 82) chain A residue 79 type sequence H description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 83) chain A residue 80 type sequence R description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 84) chain A residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 85) chain A residue 169 type sequence N description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 86) chain A residue 173 type sequence L description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 87) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 88) chain A residue 178 type sequence H description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 89) chain C residue 55 type sequence T description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 90) chain C residue 58 type sequence E description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 91) chain C residue 81 type sequence I description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 92) chain C residue 163 type sequence N description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 93) chain C residue 165 type sequence R description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 94) chain D residue 85 type sequence N description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 95) chain D residue 86 type sequence E description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 96) chain D residue 88 type sequence S description BINDING SITE FOR RESIDUE FAD A 315 source : AC7 97) chain A residue 74 type sequence R description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 98) chain A residue 75 type sequence Q description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 99) chain A residue 78 type sequence R description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 100) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 101) chain D residue 86 type sequence E description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 102) chain D residue 87 type sequence L description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 103) chain D residue 88 type sequence S description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 104) chain D residue 89 type sequence G description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 105) chain D residue 90 type sequence R description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 106) chain D residue 147 type sequence R description BINDING SITE FOR RESIDUE UMP D 318 source : AC8 107) chain A residue 55 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI2 108) chain B residue 55 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI2 109) chain C residue 55 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI2 110) chain D residue 55 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI2 111) chain A residue 75 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 112) chain A residue 174 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 113) chain B residue 75 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 114) chain B residue 174 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 115) chain C residue 75 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 116) chain C residue 174 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 117) chain D residue 75 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 118) chain D residue 174 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI3 119) chain A residue 147 type BINDING sequence R description in other chain => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI5 120) chain B residue 147 type BINDING sequence R description in other chain => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI5 121) chain C residue 147 type BINDING sequence R description in other chain => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI5 122) chain D residue 147 type BINDING sequence R description in other chain => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS source Swiss-Prot : SWS_FT_FI5 123) chain A residue 174 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000269|PubMed:27214228 source Swiss-Prot : SWS_FT_FI1 124) chain B residue 174 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000269|PubMed:27214228 source Swiss-Prot : SWS_FT_FI1 125) chain C residue 174 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000269|PubMed:27214228 source Swiss-Prot : SWS_FT_FI1 126) chain D residue 174 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000269|PubMed:27214228 source Swiss-Prot : SWS_FT_FI1 127) chain A residue 78 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 128) chain C residue 86 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 129) chain C residue 163 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 130) chain C residue 169 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 131) chain D residue 78 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 132) chain D residue 86 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 133) chain D residue 163 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 134) chain D residue 169 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 135) chain A residue 86 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 136) chain A residue 163 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 137) chain A residue 169 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 138) chain B residue 78 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 139) chain B residue 86 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 140) chain B residue 163 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 141) chain B residue 169 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4 142) chain C residue 78 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW source Swiss-Prot : SWS_FT_FI4

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