|
eF-site ID
|
3n0b-A |
PDB Code
|
3n0b |
Chain
|
A |
|
click to enlarge
|
|
Title
|
TM0449 mutant crystals grown in loops/micromounts |
Classification
|
TRANSFERASE |
Compound
|
Thymidylate synthase thyX |
Source
|
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) (THYX_THEMA) |
|
Sequence
|
A: |
HMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEE
RDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRH
RIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVT
EKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRAF
ATVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCP
WTFEAFLKYAYKGDIL
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
85 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE FAD D 300
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
86 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE FAD D 300
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
88 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE FAD D 300
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
91 |
type |
|
sequence |
Y
|
description |
BINDING SITE FOR RESIDUE FAD D 300
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
86 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE UMP A 303
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
87 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE UMP A 303
|
source |
: AC2
|
|
7)
|
chain |
A |
residue |
88 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE UMP A 303
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
89 |
type |
|
sequence |
G
|
description |
BINDING SITE FOR RESIDUE UMP A 303
|
source |
: AC2
|
|
9)
|
chain |
A |
residue |
90 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE UMP A 303
|
source |
: AC2
|
|
10)
|
chain |
A |
residue |
147 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE UMP A 303
|
source |
: AC2
|
|
11)
|
chain |
A |
residue |
30 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE FAD C 305
|
source |
: AC3
|
|
12)
|
chain |
A |
residue |
55 |
type |
|
sequence |
T
|
description |
BINDING SITE FOR RESIDUE FAD C 305
|
source |
: AC3
|
|
13)
|
chain |
A |
residue |
58 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE FAD C 305
|
source |
: AC3
|
|
14)
|
chain |
A |
residue |
81 |
type |
|
sequence |
I
|
description |
BINDING SITE FOR RESIDUE FAD C 305
|
source |
: AC3
|
|
15)
|
chain |
A |
residue |
163 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE FAD C 305
|
source |
: AC3
|
|
16)
|
chain |
A |
residue |
165 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE FAD C 305
|
source |
: AC3
|
|
17)
|
chain |
A |
residue |
78 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
18)
|
chain |
A |
residue |
79 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
19)
|
chain |
A |
residue |
80 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
20)
|
chain |
A |
residue |
81 |
type |
|
sequence |
I
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
21)
|
chain |
A |
residue |
169 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
22)
|
chain |
A |
residue |
173 |
type |
|
sequence |
L
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
23)
|
chain |
A |
residue |
174 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
24)
|
chain |
A |
residue |
178 |
type |
|
sequence |
H
|
description |
BINDING SITE FOR RESIDUE FAD A 315
|
source |
: AC7
|
|
25)
|
chain |
A |
residue |
74 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE UMP D 318
|
source |
: AC8
|
|
26)
|
chain |
A |
residue |
75 |
type |
|
sequence |
Q
|
description |
BINDING SITE FOR RESIDUE UMP D 318
|
source |
: AC8
|
|
27)
|
chain |
A |
residue |
78 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE UMP D 318
|
source |
: AC8
|
|
28)
|
chain |
A |
residue |
174 |
type |
|
sequence |
R
|
description |
BINDING SITE FOR RESIDUE UMP D 318
|
source |
: AC8
|
|
29)
|
chain |
A |
residue |
174 |
type |
ACT_SITE |
sequence |
R
|
description |
Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000269|PubMed:27214228
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
30)
|
chain |
A |
residue |
55 |
type |
BINDING |
sequence |
T
|
description |
BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
31)
|
chain |
A |
residue |
75 |
type |
BINDING |
sequence |
Q
|
description |
BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
32)
|
chain |
A |
residue |
174 |
type |
BINDING |
sequence |
R
|
description |
BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
33)
|
chain |
A |
residue |
78 |
type |
BINDING |
sequence |
R
|
description |
BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
34)
|
chain |
A |
residue |
86 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
35)
|
chain |
A |
residue |
163 |
type |
BINDING |
sequence |
N
|
description |
BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
36)
|
chain |
A |
residue |
169 |
type |
BINDING |
sequence |
N
|
description |
BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
37)
|
chain |
A |
residue |
147 |
type |
BINDING |
sequence |
R
|
description |
in other chain => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|