eF-site ID 3my0-W PDB Code 3my0 Chain W click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence W:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIKP AIAHRDFKSRNVLVKSNLQCCIADLGLAVMDIGNNPRVGT KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRT IVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIP NRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI S Description Functional site 1) chain W residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 2) chain W residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 3) chain W residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 4) chain W residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 5) chain W residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 6) chain W residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 7) chain W residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 8) chain W residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 9) chain W residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 10) chain W residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 11) chain W residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 12) chain W residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 13) chain W residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 14) chain W residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 15) chain W residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN W 600 source : CC5 16) chain W residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 17) chain W residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 18) chain W residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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