eF-site ID 3my0-U PDB Code 3my0 Chain U click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence U:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTTQLWLITH YHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEPA IAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVL WEIARRTIVVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQT PTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKT LQKIS Description Functional site 1) chain U residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN R 600 source : BC9 2) chain U residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 3) chain U residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 4) chain U residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 5) chain U residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 6) chain U residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 7) chain U residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 8) chain U residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 9) chain U residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 10) chain U residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 11) chain U residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 12) chain U residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN U 600 source : CC3 13) chain U residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 14) chain U residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain U residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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