eF-site ID 3my0-T PDB Code 3my0 Chain T click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence T:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMQLWLITHYH EHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGT QGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWA FGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKK VVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL TALRIKKTLQKI Description Functional site 1) chain T residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 2) chain T residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 3) chain T residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 4) chain T residue 229 type sequence K description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 5) chain T residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 6) chain T residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 7) chain T residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 8) chain T residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 9) chain T residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 10) chain T residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 11) chain T residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN T 600 source : CC2 12) chain T residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 13) chain T residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain T residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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