eF-site ID 3my0-O PDB Code 3my0 Chain O click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence O:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQL WLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHL HVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAV MHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESY KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDP SFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWY PNPSARLTALRIKKTLQ Description Functional site 1) chain O residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 2) chain O residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 3) chain O residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 4) chain O residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 5) chain O residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 6) chain O residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 7) chain O residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 8) chain O residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 9) chain O residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 10) chain O residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 11) chain O residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 12) chain O residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN O 600 source : BC6 13) chain O residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 14) chain O residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain O residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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