eF-site ID 3my0-M PDB Code 3my0 Chain M click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence M:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRTQLWLI THYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVE IFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHS QGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWT DIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFE DMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNP SARLTALRIKKTLQKISN Description Functional site 1) chain M residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 2) chain M residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 3) chain M residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 4) chain M residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 5) chain M residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 6) chain M residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 7) chain M residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 8) chain M residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 9) chain M residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 10) chain M residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 11) chain M residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 12) chain M residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 13) chain M residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN M 600 source : BC4 14) chain M residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 15) chain M residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain M residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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