eF-site ID 3my0-J PDB Code 3my0 Chain J click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence J:  RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW FRETEIYNTVLLRHDNILGFIASDMQLWLITHYHEHGSLY DFLQRQTLEPHLALRLAVSAACGLAHLHVEPAIAHRDFKS RNVLVKSNLQCCIADLGLAVRYMAPEVLDEQIRTDCFESY KWTDIWAFGLVLWEIARRTIVVEDYRPPFYDVVPEDMKKV VCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLT ALRIKKTLQKIS Description Functional site 1) chain J residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 2) chain J residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 3) chain J residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 4) chain J residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 5) chain J residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 6) chain J residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 7) chain J residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 8) chain J residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 9) chain J residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 10) chain J residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 11) chain J residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 12) chain J residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 13) chain J residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 14) chain J residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 15) chain J residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain J residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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