eF-site ID 3my0-I PDB Code 3my0 Chain I click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence I:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMQLWLITHYH EHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGT QGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWA FGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKK VVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL TALRIKKTLQKIS Description Functional site 1) chain I residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 2) chain I residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 3) chain I residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 4) chain I residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 5) chain I residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 6) chain I residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 7) chain I residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 8) chain I residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 9) chain I residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 10) chain I residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 11) chain I residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 12) chain I residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 13) chain I residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 14) chain I residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 15) chain I residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN I 600 source : AC9 16) chain I residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 17) chain I residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 18) chain I residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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