eF-site ID 3my0-G PDB Code 3my0 Chain G click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source null (ACVL1_HUMAN) Sequence G:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW AFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR LTALRIKKTLQKIS Description Functional site 1) chain G residue 208 type sequence V description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 2) chain G residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 3) chain G residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 4) chain G residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 5) chain G residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 6) chain G residue 279 type sequence Y description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 7) chain G residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 8) chain G residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 9) chain G residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 10) chain G residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 11) chain G residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 12) chain G residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 13) chain G residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN G 600 source : AC7 14) chain G residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN J 600 source : BC1 15) chain G residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 16) chain G residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain G residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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