eF-site ID 3my0-E PDB Code 3my0 Chain E click to enlarge Title Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 Classification TRANSFERASE Compound Serine/threonine-protein kinase receptor R3 Source Homo sapiens (Human) (ACVL1_HUMAN) Sequence E:  MQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSS RDEQSWFRETEIYNTVLLRHDNILGFIASDMTQLWLITHY HEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFG TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW AFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR LTALRIKKTLQKIS Description Functional site 1) chain E residue 216 type sequence V description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 2) chain E residue 227 type sequence A description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 3) chain E residue 257 type sequence L description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 4) chain E residue 277 type sequence T description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 5) chain E residue 278 type sequence H description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 6) chain E residue 280 type sequence H description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 7) chain E residue 281 type sequence E description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 8) chain E residue 283 type sequence G description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 9) chain E residue 287 type sequence D description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 10) chain E residue 334 type sequence R description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 11) chain E residue 335 type sequence N description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 12) chain E residue 337 type sequence L description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 13) chain E residue 347 type sequence A description BINDING SITE FOR RESIDUE LDN E 600 source : AC5 14) chain E residue 291 type sequence R description BINDING SITE FOR RESIDUE LDN H 600 source : AC8 15) chain E residue 330 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 16) chain E residue 229 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain E residue 208 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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